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Finally, a profound decrease in astrocytic expression of Cx43 was found in the post-mortem samples of patients with advanced-stage PD

The 2-hydroxy metabolic pathway is considered good as it has the lowest risk for chronic illness

Its intracellular concentration equals from 1 to 15 mM [27,28]

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However, the in vitro data indicate that this cytotoxicity and the perforin expression levels in NK cells appear to be dependent upon endogenous IGF-1 and miR-483-3p expression, given that they can be inhibited by either IGF-1-neutralizing antibody or miR-483-3p overexpression

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