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They used fifteen male C57BL/6 mice (4 weeks old) were initially fed a high-fat diet (45% fat) for 12 weeks to induce obesity, followed by a low-fat diet (10% fat) for 8 weeks

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A landmark 2009 study published in Neuro Endocrinology Letters by Maes et al

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Probiotics were shown to be beneficial in lowering serum hormone fluctuations (188), partly because iodothyronines deconjugation is regulated by bacterial enzymes sulfatases and -glucuronidases whose availability could be increased by probiotic supplementation (189)

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