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Abstract Estrogen-related receptors (ERR//) are ligand-responsive nuclear receptors that coordinate oxidative metabolism, mitochondrial biogenesis, and substrate selection in energetically active tissues

doi: 10.1016/S0140-6736(11)60205-5

ISBN 9781442564411

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In terms of immunometabolic regulation, multiple studies in tumor and inflammatory models have shown that the PI3K/Akt/mTOR pathway can support macrophage polarization toward an M2-like phenotype by promoting metabolic reprogramming processes such as oxidative phosphorylation and fatty acid oxidation (107, 109)

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