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Transactivation of NRF2 in KO livers was further supported by constitutive induction of NRF2 target genes, including Gclc , metallothionein I ( Mt1 ) and heme-oxgenase 1 ( Hmox1) (Fig

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It was shown that the toxicity of OTA could be decreased by maintaining glutathione production with N -acetyl cysteine (NAC), which decreased reactive oxygen species (ROS) and 8-oxoguanine formation