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Intervention strategies targeting these axessuch as modulating gut microbiota, peripheral immunity, or hepatic metabolismmay offer novel directions for disease-modifying therapies in PD

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Among them, drug-carrier delivery into the brain assisted by FUS-induced BBB opening, could be a promising approach to address this unmet need because of its site-specificity, noninvasiveness, and applicability to a wide range of therapeutics

237 These nanoparticles typically integrate photothermal materials with metals possessing Fenton reaction catalytic activity to create hollow nanostructures, allowing for the loading of chemotherapeutic drugs like doxorubicin (DOX)

Khatri DK, Preeti K, Tonape S, Bhattacharjee S, Patel M, Shah S, Singh PK, Srivastava S, Gugulothu D, Vora L, Singh SB

Polysomnography studies measuring sleep stages in sermorelin users documented increased time spent in deep sleep