mitochondrial damage glutathione Probe for Depletion Reveals NME3 Essentiality for Mitochondrial Redox Response Mitochondrial injury and glutathione depletion

Another crucial mechanism of l-glutathione reduced is its role in detoxification processes

Alternatively, P53 enhances the sensitivity of cells to ferroptosis by enhancing the expression of spermidine/spermine N1-acetyltransferase 1 (SAT1) and glutaminase 2 (GLS2) and inhibiting cystine uptake [101,102,103]

Abbreviations BBB: Blood-brain barrier BER: Berberine CS: Chitosan DMSO: Dimethyl sulfoxide EE %: Percentage entrapment efficiency GFAB: Glial fibrillary acid protein GSH: Reduced glutathione IHC: Immunohistochemistry MAO-B: Monoamine oxidase B MPTP/P: 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine PDI: Polydispersity index PD: Parkinsons disease SOD: Superoxide dismutase TEM: Transmission electron microscopy TNF-: Tumor necrosis factor alpha References Cheng Z, Kang C, Che S, Su J, Sun Q, Ge T, Guo Y, Lv J, Sun Z, Yang W, Li B, Li X, Cui R

Nearby metal ions or cofactors may also perturb redox potential

Ishida, T

Thromb Haemost 2020