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PM under different animal models of human diseases Some studies have used PM as a model to study sexual dysfunctions in women since it is possible to dissociate motivational and consummatory aspects after pharmacological treatments

CRP can also increase bloodbrain barrier paracellular permeability and enter the brain parenchyma in mice with adult-onset obesity in a dose-dependent manner [144]

DOI: 10.1038/sj.ejcn.1602109

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Sexual and appetite effects can show up faster but vary widely from person to person