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Rating the quality of evidenceStudy limitations (risk of bias) J

Gout has been identified as an independent risk factor for chronic kidney disease, nephrolithiasis and acute kidney injury, wherein uric acid excretion by the kidneys participate in facilitating crystal-induced direct tubular toxicity
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The cholesterol-independent mechanism of statins is through the reduction of mevalonate, which is essential for neuronal survival (Moutinho et al., 2017)

Cholinergic drug intoxication
Pakos-Zebrucka, K
