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In addition, several enzymes engaged in mitochondrial respiration are found to regulate ferroptotic cell death, such as SCO2 and fumarate hydrase (FH)[44, 116]

Fibroids deficient in FH exhibit an impairment in oxidative phosphorylation and a resultant metabolic shift to aerobic glycolysis [37]

Do not exceed the recommended

Larger trials conducted on a broader population would be valuable in confirming these findings and establishing GSH as a neuroprotective agent in clinical practice

Alkaloids contain nitrogen-containing heterocyclic structures, a feature highly similar to that of most classic antidepressants

484 Since the severe toxicity of high-dose IL-2 and IFN- leads to the intolerance of patients to treatment and restrains the therapeutic efficacy in a large population, the combination of chemotherapies, targeted therapies or other immunotherapies with low-dose IL-2 or IFN- has been employed in some investigations to avoid the side effects brought by single high-dose cytokines therapy, which can meanwhile achieve better treatment response