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Indeed, the interpretation of TSPO binding is complex, with the authors of a recent review stating: At present, it is not clear whether the presence of TSPO PET signal indicates a predominantly pro-inflammatory or anti-inflammatory state, nor whether the signal indicates the presence of destructive or reparative cell states. [73]

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Histopathological and experimental models of diabetic neuropathy further demonstrate axonal degeneration, segmental demyelination, and Schwann-cell alterations consistent with chronic ischaemicmetabolic nerve injury [19]

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However, after one month of antibiotics withdrawal, TMAO levels are detected again [21,124]