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doi: 10.1007/s11154-022-09778-x 29 TangJShanSLiFYunP

Interpreting limits of past ULT trials A guiding doctrine of the ACP guideline was that retrospective studies and even RCTs that used the decline in serum urate level to a pre-stipulated target as an indirect, surrogate outcome, rather than demonstrating the improvement in a clinical outcome such as reduction in frequency of acute gout flares during the randomized phase of an RCT, were insufficient data for the standard of evidence-based guidelines defined by the Institute of Medicine (since renamed the National Academy of Medicine) 40

LKB1 is a serine/threonine kinase that functions as a master regulator of cellular energy homeostasis through activation of AMPK and related kinases

This information helps inform decisions about continued use and identifies any concerning trends early

Efficacy of epratuzumab, an anti-CD22 monoclonal IgG antibody, in systemic lupus erythematosus patients with associated sjogren's syndrome: post hoc analyses from the EMBODY trials

Two ml (0.3 mL/s) warmed Omnipaque 350 (iohexol) non-ionic contrast medium (GE Healthcare, United States) was injected into the inferior vena cava at the level of bifurcation of rats with a suprahepatic occlusion of the inferior vena cava