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Eur J Appl Physiol 111:3746

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Electron leak largely occurs at the sites of complex I (NADHubiquinone oxidoreductase) and complex III (ubiquinonecytochrome c oxidoreductase) in the ETC and results in the partial reduction of oxygen, generating superoxide

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Lipid peroxidation is a chain reaction initiated when ROS, particularly OH and Hydroperoxyl (HO 2 ) generated from , combine with a hydrogen atom from a fatty acid to produce a lipid radical