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758 This metabolic adaptation also affects stromal cancer-associated fibroblasts (CAFs), influencing their oxidative stress and aerobic glycolysis

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Smith, BR & Brown, CD (2023)

Th17 cells depend on FAS for membrane biosynthesis and inflammatory signaling, requiring enzymes such as acetyl-CoA carboxylase 1 (ACC1) and fatty acid synthase (FASN) ( FAO-driven OXPHOS is necessary for Treg cells to continue their suppressive role ( In summary, lipid metabolism orchestrates Th17/Treg balance through multiple interconnected mechanisms: extracellular lipids provide environment-dependent signals, endogenous synthesis and oxidation pathways fuel functionally distinct metabolic states

However, temporal associations in this case were complicated by several factors

doi: 10.3390/antiox9020125 82