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Drug Discovery , 2011, vol
One study found that the lowest dose of cyanocobalamin required to correct B12 deficiency in seniors is more than 200 times greater than the recommended dietary allowance (approximately 3 g daily)

However, there are new drugs in development that show promise

Behere RV, Deshmukh AS, Otiv S, Gupte MD, Yajnik CS
Early events in the pathogenesis of chronic obstructive pulmonary disease

Highlights Proposing a green ionic liquid based microemulsion based on multi-scale analyses
