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L-Glutathione is the most effective formulation for having bright skin and removing toxic substances in the skin

However, one ages, the ability of the liver to produce glutathione deteriorates, which in turn, causes skin pigmentations, sagging, and wrinkled skin

Decreased GSH leads to a cascade of events, including an inability to mitigate oxidative stress, a subsequent increase in the release of cytokines IL-6 and TGF-, both of which are shown to further decrease GSH synthesis, and an increase in platelet activation, contributing to microclot formation

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Yes, glutathione is often used in skincare to lighten skin

PLoS Biol 5(10):e261