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237 PhelanS
1994 May;125(4):929-43

The inflammatory component often improves before structural healing becomes apparent

[3] Calabrese, G., Morgan, B

In a PD mice model induced by MPTP, baicalein inhibits the NLRP3/Caspase-1/GSDMD Pathway to decrease neuroinflammation (Rui et al., 2020)

Think of the peptide as a key and the receptor as a lock: constant use wears the mechanism, and a planned off period lets it resensitize
