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Abrogating effect of N-linked carbohydrate modifiers on the stem cell factor and endothelin-1-stimulated epidermal pigmentation in human epidermal equivalents

a: Volcano plot showing the metabolome of Mtb plotted as the fold change in the mean abundance of each feature in glpQ 1 strain/parent strain, showing positive ion-mode

Supporting Metabolism Metabolism refers to how the body converts food into fuel

The synthesis of pyruvate occurs nearly exclusively in the cytosol and its oxidation occurs exclusively in the mitochondria, therefore transport into the mitochondria is critical for overall pyruvate homeostasis

While GSH depletion is associated with diseases such as type II diabetes, non-alcoholic fatty liver disease, and Parkinsons disease, GSH levels are frequently upregulated in cancer 4,814 However, whether GSH dysregulation is causative or symptomatic of disease progression in these diverse settings remains poorly understood