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Clinical Pharmacology & Therapeutics 2010;88(3):4125

adults have been diagnosed with liver disease

Cannabinoid receptors are also activated by endogenous ligands, the en-docannabinoids, a family of endogenous arachidonic acid derivatives, including N-arachidonylethanolamide (anandamide) and the 2-arachidonoylglycerol which is synthesized by the cell membrane (Sugiura et al., 2002)

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GPx4 uses GSH as a reducing substrate and converts it into oxidized form, also referred to as glutathione disulphide (GS-SG) ( NFE2L2 gene) (Habib et al., 2015), the xCT mRNA can be positively regulated by the activation of transcription factor 4 (ATF4) under oxidative stress (Sato et al., 2004), while its negative regulation by p53 results in cysteine deprivation and increased susceptibility to ferroptosis (Jiang et al., 2015)

Our clinical analyses extend these findings by demonstrating that serum ferritin independently predicted IR in patients with MASLD, even after rigorous adjustment for confounding factors such as age, BMI, lipid profiles, and hepatic pathology