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Moreover, the presence of HSP60 on the cell surface and in the extracellular milieu has been linked with the activation of immune responses, where it acts as a damage-associated molecular pattern (DAMP) and signals to immune cells, thereby influencing inflammatory pathways, 134,135 which is particularly relevant in understanding autoimmune diseases and cancer

FIGURE 2 Apoptosis and ATG are processes altered in cancer cells that show critical metabolic transformations associated with enhanced cellular stress

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Experimental obstructive cholestasis: the wound-like inflammatory liver response

In humans, the gut microbiome is affected by many different factors, making the connection between KD, gut microbes and neuroprotection currently only correlative and requiring further study