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doi: 10.1073/pnas.1417232112

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To elucidate the relationship between iron homeostasis and metabolic features in clinical cases of MASLD, we conducted a comprehensive analysis of serum ferritin, a marker of iron stores, and its associations with diverse metabolic parameters in a well-characterized MASLD cohort (Figure 1A)

Neuromelanin released from dying DA neurons in the SNpc activate microglia, increasing the sensitivity of DA neurons to oxidative stress-mediated cell death ( Dopamine neurons containing neuromelanin are especially more susceptible, indicating a possible role for neuromelanin in MPTP-toxicity ( Parkinsons disease-associated proteins like -syn, parkin, LRRK2, and DJ-1 have also been reported to activate microglia ( Conclusion The elements that potentially cause oxidative stress in PD are still unknown