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The extensive degeneration of these DA neurons results in diminished dopamine levels within the brain, which gives rise to a spectrum of clinical manifestations, encompassing challenges in maintaining posture, the emergence of stationary tremors, a decrease in movement speed (bradykinesia) and the onset of joint stiffness reminiscent of ankylosing arthritis (49)

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Because there are no symptoms in carriers, its hard to know exactly how many people in the general population have an abnormal copy of the gene

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