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It is unknown whether this downregulation is the primary cause of the disorder, but it is likely to be a contributing factor

Multiple observational studies (see this and this

Lee J, Roh KB, Kim SC, Lee J, Park D (2012b) Soy peptide-induced stem cell proliferation: involvement of ERK and TGF-1

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In vitro experiments have shown the formation of the reactive metabolite NAPQI and N-acetyl-p-benzosemiquinone imine (NAPSQI) by prostaglandin H 2 synthases (PTGS) [38,39]
