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Reduction of oxidative stressinduced hyperpigmentation Oxidative stress from UV exposure, pollution, and inflammation can stimulate melanocytes and trigger excess melanin production, leading to dark spots and uneven tone

A catalytic cycle of GPx (Figure 2) starts with the oxidation of the selenol (ESeH) moiety of Sec residue by peroxide to generate the selenenic acid (ESeOH) [37, 38], which reacts with cellular thiol (glutathione, GSH) to generate a selenenyl sulfide intermediate (ESeSG)

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As of her interview with this author on April 6, 2020, Lucy is stable on 200 mg of morphine sulfate (compared to 1800 mg at baseline), 30 mL hydromorphone twice daily (compared to 170 mL twice daily at baseline), and is completely off street drugs (compared to using about three points, or 300 mg, of fentanyl daily at baseline)