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An important model to study the consequences of systemic carnitine deficiency is the homozygous OCTN2 null mouse, in which OCTN2 function is abolished by the missense mutation L352R

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To this end, the active members of the Neuropathic Pain Special Interest Group of the Italian Neurological Society (NPG), who recently contributed to the diagnostic guideline for fibromyalgia [3], reviewed the most recent RCTs and answered questions that yielded a consensus on the main pharmacologic and non-pharmacologic approaches