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BECN1, when phosphorylated by p38 mitogen-activated protein kinase (p38MAPK), can directly bind to the subunit SLC7A11 of the Xc- system, blocking the ability of the Xc- system to transport Cys, inhibiting GSH synthesis, and promoting ferroptosis (Kang et al., 2018

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The incorporation of a D-amino acid and methylated tyrosine increases resistance to enzymatic degradation and enhances mitochondrial uptake in laboratory studies

Hamid, F