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For instance, Whitehouse et al

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Its dysfunction allows the infiltration of diverse immune cells and systemic markers into the brain parenchyma [190]

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Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization)

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Adult patients were divided into childhood-onset and adult-onset groups based on age of onset, with separate networks constructed for comparison

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doi: 10.1016/j.ejso.2014.11.037

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