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For instance, Whitehouse et al

Its dysfunction allows the infiltration of diverse immune cells and systemic markers into the brain parenchyma [190]

Occupancy stays low, but each engaged receptor keeps sending its main message longer than it would under a balanced signal (cAMP bias with low receptor internalization)

Adult patients were divided into childhood-onset and adult-onset groups based on age of onset, with separate networks constructed for comparison

doi: 10.1016/j.ejso.2014.11.037

Respectfully sir, I disagree
