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(2) Diagnostic criteria for pernicious anaemia there must be laboratory evidence of (a) macrocytic anaemia

Methylcobalamin is required for the creation of S-adenosylmethionine (SAM), the most important methyl donor in the human body

, 2022), and (Akta, 2020)

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A less than optimal production of red blood cells may lead to a lowered oxygen carrying capacity of the blood, resulting in insufficient muscle perfusion