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However, when GPX4 mito was down-regulated with GPX3 knockdown, the expression level of DHODH in mitochondria increased, whereas GPX3 overexpression did not affect it

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A retrospective analysis by Howard et al

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203 In another study, SOD1-G93A mice were treated with caprylic triglyceride, a medium-chain TG that is metabolized into KBs and can serve as an alternative energy substrate for neuronal metabolism