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Although single-cell transcriptional profiling shows substantial microglial heterogeneity across brain regions in PD, limited sample sizes currently restrict definitive conclusions [267]

& Axelsen, P

These studies indicate that in ALL, the development of DTP cells is mediated by transcriptional and epigenetic machinery and regulated by unique signaling pathways

Mfn2 ablation causes an oxidative stress response and eventual neuronal death in the hippocampus and cortex

If the trials show efficacy that Im not expecting (the primary endpoint is the same as used for the approved beta-amyloid monoclonal antibody drugs, change in Clinical Dementia Rating Sum of Boxes score) that would be great

FAO of exogenous, 14 C-labeled fatty acids shows that both FASN lox/lox -PyMT and FASN / -PyMT MEFs oxidize fatty acids, although FASN / -PyMT MEFs do soas expectedat a lower rate (Supplementary Fig