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The arginine substitution at position 3 greatly reduces the peptides affinity for IGFBPs by about 100-fold compared to native IGF-1

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10.1038/ng0793-227

Interestingly, H 2 S also has a heterotypic interaction with another important signaling molecule, NO, for example, H 2 S can promote endothelial NO production via activating NOS phosphorylation (100)