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Effects of controlled dynamic disc distraction on degenerated intervertebral discs

High-dose IV vitamin C can reach blood concentrations that enhance antioxidant activity, but dramatic visible changes from a single session are uncommon

Necrotic death leads to the leakage of intracellular oxidative and inflammatory components, which then propagate more inflammation, oxidative stress, and death in neighboring cells (Figure 5) (173)

This suggests that components involved in TJ disassembly may represent useful therapeutic targets by limiting the impact of enteric pathogens on intestinal barrier integrity and restricting their systemic spread

In the clinic, we consider factors such as poor inflammatory regulation, nutrient deficiencies, a disrupted gut microbiome, or impaired mitochondrial function