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Isochorismate is then the substrate for PHYLLO, 42 a trifunctional enzyme with 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-2-carboxylate (SEPHCHC) synthase, 2-succinyl-6-hydroxy-2,4-cyclohexadiene-2-carboxylate (SHCHC) synthase and OSB synthase domains (reactions 24, Figure 2)

Single-target drugs often produce inconsistent results because biological systems are interconnected

Complementary Therapies in Medicine, 15: 77-83

Nat Chem Biol (2020) 16(12):135160

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