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The inhibition of elastase allows flavonoids to assume a protective function, improving clinical outcomes in multiple respiratory diseases (304)

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& Anderson, W

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In contrast, glycine (and D-serine) can facilitate excitatory neurotransmission by serving as an obligatory co-agonist at NMDA receptors, thereby influencing receptor gating, synaptic plasticity, and downstream signaling in cortical and hippocampal circuits

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While FK866 monotherapy typically requires high doses (for example, 1520 mg/kg twice a day) 190,191 , synergistic efficacy in combination regimens has been achieved at substantially lower doses (approximately 5 mg/kg daily) 188 , thereby widening the therapeutic window

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