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Dihexa acetate can amplify the binding efficiency of HGF and c-Met receptors in vivo with high affinity, activate downstream Akt and ERK cell survival signaling pathways, inhibit neuronal apoptosis, accelerate the generation of new synaptic structures, and remodel the brain's neural synaptic network structure

Funding The work was financially supported by Research University Team (RU Team) Grant from Universiti Sains Malaysia (Grant code: #2025/622/TE113)

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