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They used AppNl-G-f mice which carry three APP knockout mutations with familial AD causing elevated levels of A 42 and observed decreased amyloid deposition, a decline in P-tau-positive areal fraction in the hippocampus ( p 3.0.CO;2-N) [DOI] [PubMed] [Google Scholar] 130.Vouldoukis I, Conti M, Krauss P, Kamat C, Blazquez S, Tefit M, Mazier D, Calenda A, Dugas B

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Bryant JC, Westphal RS, Wadzinski BE

Cosegregation analysis of these candidate mutations was conducted within the family

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In Vitro GSH Skin Permeation Tests To investigate the ex vivo permeation kinetics across the skin of the reduced-GSH released from the GSH 2.5 -HA MN patches, static diffusion Franz cell tests were performed to calculate the rate of time-dependent GSH release through GSH 2.5 -HA MNs and its diffusion through the skin along with a reference GSH-HA solution