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The 2013 Journal of Neurochemistry paper by McCoy et al

Experimental studies consistently demonstrate that magnesium deficiency enhances neutrophil activation and reactive oxygen species (ROS) production while suppressing antioxidant defense systems, thereby promoting lipid peroxidation and oxidative hepatocellular injury ( + redox balance, impair fatty acid -oxidation, and reduce ATP synthesis, collectively compromising hepatocellular energy homeostasis ( Hypomagnesemia disrupts cellular calciummagnesium homeostasis, often leading to relative calcium overload

The slow escalation exists specifically because faster titration produces more nausea, more vomiting, and more discontinuations

Kim H, Ji HW, Kim HW, et al

Like many therapeutic peptides, it may require daily (or near-daily) administration, as in the previously referenced mouse and rabbit studies.12 17 Moreover, as a preventive or a drug for managing chronic health conditions, treatment ought to be ongoing and may involve periodic breaks in dosing (cycling), which is also common with many therapeutic peptides

doi: 10.1007/s12035-021-02658-6 294 VieiraF