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Metalloproteinases can digest collagen and elastin, weakening the skin and causing sag

Lancet 1 , 447451 (1977)

Front Pharmacol 12:693983 Zhou L, Feng Y, Jin Y, Liu X, Sui H, Chai N, Chen X, Liu N, Ji Q, Wang Y, Li Q (2014) Verbascoside promotes apoptosis by regulating HIPK2-p53 signaling in human colorectal cancer

Chronic microglial activation has been identified as a mechanism behind excessive synaptic pruning, loss of brain volume in the cortex and cellular dysfunction in the PFC, all of which are characteristic pathologies of psychosis in schizophrenia [49]