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Additionally, it mitigated learning and memory impairment by regulating NF-B/toll-like receptors 4 (TLR4)/Nrf2 pathways, reducing astrogliosis biomarkers, restoring cholinergic function, and modulating the inflammatory response (63)

The results suggest that NZB/W mice have increased expression of senescence markers such as FOXO4, rH2AX, and p16, and that senescent cells can be targeted in the kidney of patients with lupus

[DOI] [PMC free article] [PubMed] [Google Scholar] 26.Hofkens W., Schelbergen R., Storm G., Van Den Berg W.B., Van Lent P.L

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In tandem with pharmacologic innovations, digital therapeutics are also transforming the treatment landscape