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1,2,6 Neurologic manifestations are caused by progressive demyelination and can include peripheral neuropathy, areflexia, and the loss of proprioception and vibratory sense

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Following this, the binding of cobalamin to a second glycoprotein, _intrinsic factor_, promotes its uptake by terminal ileum mucosal cells by a process called _cubilin_/AMN receptor-mediated endocytosis

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The BSH Guidance The British Society for Haematology (BSH) published a Guidance on treating Pernicious Anaemia during COVID-19 early April which caused some confusion and we worked with the BSH and two of our experts to produce a new and better Guidance which was issued at the end of April