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The first attempts to measure intestinal permeability in IBD were performed in the late seventies by rectal instillation of radioiodine-labeled albumin and by measuring later the radioactivity in the plasma in healthy subjects and patients with UC (101)

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The structure calculations performed by the research team suggests that the hydrophobic face of the peptide is bound deep within the binding pocket of HDM-2 and is not able to interact with the lipids present in the membrane bilayer