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Side-effects of topical steroids: A long overdue revisit
2014;7:e28231
doi: 10.1007/s11033-024-09737-6 109 KhounganianRAudaSAl-ZaqzouqRAl-SemariHShakeelF
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Since ATF3 is a bona fide substrate of E3 ligase MDM2, MDM2 is the only E3 ligase so far known to degrade ATF3 ( Strikingly, our data revealed that by binding with RING domain of MDM2, PXR decreased MDM2 protein expression, enhanced polyubiquitination of MDM2, and reduced MDM2 protein half-life ( Figure 5 )
Curr Opin Lipido
