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About this article Cite this article Zheng, M., Zhu, W., Gao, F

When folate cycling is impaired by MTHFR insufficiency, the dihydrofolate THF step accumulates dihydrofolate, competing with the BH2 BH4 reduction step for DHFR activity and NADPH

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[DOI] [PubMed] [Google Scholar] 57.Popat A, Shear NH, Malkiewicz I, et al

Importantly, the Flag-tagged point mutant of gp34 1-179 with a tryptophan to phenylalanine substitution at position 65 (gp34 1-179W65F ) (Fig

Na + ,K + -ATPase activity is required both to support NKCC1 function, since NKCC1 operates as a secondary active transporter supported by Na + ,K + -ATPase-generated ion gradients, and to maintain conditions allowing inward channel-mediated transport