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Subjects/methods Between January 2018 and December 2020, a total of 418 T2DM patients with or without insomnia were recruited

In the last decades, IGF-1 has been implicated in many physiological actions, among others: tissue growth and development, proliferative, lipid metabolism, pro-survival/anti-aging, anti-inflammatory, anabolic, and antioxidant with neuro- and hepatoprotective properties [105116]

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