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doi: 10.1038/nature13198

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Maintenance doses are given less often than initial doses

Metformin use and risk of B12 deficiency increases with the dose and the duration depletion can be seen as early as 3-4 months after starting so it is important to attend for follow up blood tests and talk to your doctor

In essence, adding Vitamins B6 and B12 ensures a comprehensive approach to managing diabetes and obesity, maximizing the benefits of your treatment plan

Gradually increasing within standard ranges may help