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In one illustrative, but non-limiting embodiment, the signaling domain of CD3-zeta is encoded by a nucleic acid that comprises or consists of the sequence AGAGTGAAGT TCAGCAGGAG CGC AGACGCC CCCGCGT AC A AGC AGGGCC A GAACC AGCTC T ATAACGAGC TCAATCTAGG AC G A AG AG AG GAGT AC GATG TTTTGGACAA GAGACGTGGC CGGGACCCTG AGATGGGGGG AAAGCCGAGA AGGAAGAACC CTCAGGAAGG CCTGTACAAT GAACTGCAGA AAGATAAGAT GGCGGAGGCC TACAGTGAGA TTGGGATGAA AGGCGAGCGC (SEQ ID NO:81)

doi: 10.1111/j.1476-5381.1990.tb12977.x

Limitations The most common limitation across all included studies is small sample sizes

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Glutathione reduces melanin It shifts dark melanin (eumelanin) to lighter melanin (pheomelanin)

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