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It has been reported that these three compounds can enhance the contents of GSH and the activities of GSH-dependent antioxidant enzymes (GPX and GST) and reduce lipid peroxidation and cardiac damage mediated by DOX or isoproterenol (ISO) in the myocardium of rats, respectively [121, 129, 130]

GPX4 was first purified by Ursini and colleagues through biochemical technology [69]

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10.1016/S0006-2952(02)01173-5 Biochem

Certain phytochemicalsincluding flavonoids and tanninshave metal binding activity for cadmium, nickel, aluminum, and lead in vitro and in vivo