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Benzo[]pyrene, a PAH, undergoes metabolic activation by the phase I enzymes cytochrome P450 (CYP)1A1/B1 to the highly carcinogenic benzo[]pyrene-7,8-dihydrodiol, which is oxidized by AKR1A1 to form the corresponding ketol followed by rearrangement and oxidation to O -quinone with concomitant generation of ROS [47,54]

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& Ghigo, J

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It strongly binds remaining toxins and plays a role in aiding antidotes such as N-acetylcysteine (NAC) for paracetamol toxicity

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time to reach half the steady-state P ss /2 Taking the to both sides, It must be noticed that the time to reach half the steady-state has the same value for the elimination half-life and is dependent on the elimination process the infusion rate while the value of C ss is controlled by the infusion rate

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Our group recently described that a genetic disruption of the xCT subunit using CRISPR-Cas9 inhibits protein synthesis and proliferation in vitro ( 14 C-cystine transport assay in xCT knockout (xCT-KO) cells revealed this transporter as unique and indispensible for cystine uptake, as a complete abolishment of cystine transport has been observed

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Considering the critical importance of CBF delivery in maintaining neuronal health and function, these findings alone warrant further interventional investigations on how long-term RT affects cerebrovascular function in older adults across the cognitive and neurodegenerative spectrum

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