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Immunity 41 , 7588 (2014)

Although our findings argue against further exploration of ALCAR/ALA (at least at the doses used here) for treatment of bipolar depression, other mitochondrial-enhancing compounds, such as N-acetylcysteine (NAC), coenzyme Q10 (CoQ10), and creatine monohydrate, might have more potent effects on mitochondrial functioning and hence greater antidepressant efficacy

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doi: 10.3389/fneur.2026.1735762 Received 30 October 2025 Revised 13 April 2026 Accepted 20 April 2026 Published 04 May 2026 Volume 17 - 2026 Edited by Amit Kumar Madeshiya, The University of Texas Health Science Center at San Antonio, United States Reviewed by Olga V

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