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The orobuccal and sublingual routes have been explored to overcome oral glutathiones absorption and bioavailability challenges: Orobuccal formulations: Glutathione is absorbed directly in the oral cavity, which generates much quicker absorption and considerably higher bioavailability

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Notably, HIF-1 stabilizing drugs have already gone through all clinical phases for their safety and efficiency in the context of anemia 61,62

Vestergaard, A

However, due to the lack of selectivity to the lesion microenvironment, their therapeutic efficiency is often limited and accompanied by severe side effects and drug resistance problems (Wang et al., 2024c)

Conversely, mouse libraries were sequenced by Novogene facility using Novoseq X plus (Illumina) sequencer employing a paired-end approach