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A study conducted on rats revealed that in ASD, there was significantly lower histone acetylation and higher HDAC2 expression in the PFC

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The positive role of glutathione in preventing hypertension may also be explained by the observations that high glutathione levels prevent platelet-derived growth factor (PDGF)-mediated production of ROS by NADH/NADPH oxidase, which is considered to be the main source of vascular ROS (7), (22)

However, it remains unclear whether lactylation is merely a natural consequence of elevated lactate levels or if it requires specific regulatory factors for precise modulation

In the modified intent-to-treat population (n = 145), the mean ln ratio in PWT was 0.241 for the cilostazol + L-carnitine treatment group versus 0.134 for the cilostazol + placebo treatment group (p = 0.076)